Mycophenolate Mofetil, combined with corticosteroids and either ciclosporin or tacrolimus, is used for:
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Cellcept 500mg Tablet 10's falls under the category of ‘immunosuppressants,' used to prevent rejection of transplanted organs like kidneys, hearts, or livers. Transplant rejection happens when the recipient's immune system sees the transplanted organ as foreign and attacks it. This medication contains 'Mycophenolate mofetil,' which, when combined with another immunosuppressant and anti-inflammatory agent, inhibits T and B lymphocytes (white blood cells attacking foreign cells) and reduces antibody production. These effects dampen the immune response, preventing rejection of the transplanted organ.
Take Cellcept 500mg Tablet 10's exactly as prescribed by your doctor, who will determine the dosage based on your medical condition. Common side effects may include diarrhea, vomiting, lowered white and red blood cell counts, and susceptibility to infections. If these side effects persist or worsen, consult your doctor.
Do not use Cellcept 500mg Tablet 10's if you are allergic to 'mycophenolate mofetil' or any of its ingredients. Avoid it if you are pregnant, planning a pregnancy without contraception, or breastfeeding, as it can harm the unborn baby. Pregnant women should take a pregnancy test before using this medication. Employ effective contraception while on Cellcept 500mg Tablet 10's. Protect yourself from sunlight to minimize the risk of skin cancer, and be aware that it increases susceptibility to infections due to immune suppression. Inform your doctor before donating blood or sperm, and avoid vaccinations as they may be less effective.
Consumption of alcohol may worsen the condition by increasing the risk of side effects.
Cellcept 500mg Tablet is unsafe for use during pregnancy as it can cause miscarriage or birth defects. Contact your doctor immediately if you suspect pregnancy while taking this medicine.
Due to the lack of safety information, Cellcept 500mg Tablet is not recommended for use while breastfeeding.
Do not drive or operate any machines if you feel drowsiness, somnolence, dizziness, tremor, low blood pressure, numbness or confusion after taking Cellcept 500mg Tablet.
Cellcept 500mg Tablet should be used with caution in patients with kidney diseases. Contact your doctor before taking Cellcept 500mg Tablet.
Cellcept 500mg Tablet should be used with caution in patients with liver diseases. Contact your doctor before takingCellcept 500mg Tablet.
Cellcept 500mg Tablet falls under the category of immunosuppressants, which work to suppress the body's immune system and thereby prevent the rejection of transplanted organs.
Mycophenolate Mofetil acts as an immunosuppressive agent by functioning as an uncompetitive and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This action hinders the de novo pathway of guanosine nucleotide synthesis without affecting DNA incorporation. As a result, Mycophenolic acid exerts cytostatic effects on lymphocytes. It has demonstrated its ability to prevent acute rejection following kidney and heart allograft transplantation. Additionally, it reduces the production of antibodies.
The active compound mycophenolic acid, derived from mycophenolate mofetil, functions by inhibiting inosine monophosphate dehydrogenase (IMPDH), an enzyme crucial for the de novo synthesis of guanosine nucleotides. This inhibition interrupts the production of necessary substrates for DNA and RNA synthesis. Lymphocytes, particularly T and B cells, rely heavily on this de novo pathway for generating guanosine nucleotides, making them more vulnerable to the effects of mycophenolic acid compared to other cell types that can utilize alternative pathways.
Mycophenolic acid acts as a non-competitive and reversible inhibitor of IMPDH. Its mechanism of action involves mimicking both the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule, thereby hindering the oxidation of inosine monophosphate (IMP) to xanthose-5’-monophosphate. This step is essential in the de novo biosynthesis of guanosine nucleotides. The resultant reduction in intracellular levels of guanosine triphosphate (GTP) and deoxyguanosine triphosphate (dGTP) curtails the proliferation of lymphocytes, particularly T and B cells, due to their heavy reliance on the de novo guanosine synthesis pathway.
The pharmacodynamic effects of mycophenolic acid involve inhibiting mixed lymphocyte responses and the proliferation of human peripheral blood lymphocytes induced by various mitogens and antigens. However, mycophenolic acid does not impact GTP concentrations in human neutrophils. This selective inhibition of lymphocyte proliferation underpins its immunosuppressive action, making it particularly effective in preventing transplant organ rejection.
Transplant Patients:
Prophylaxis of Renal Rejection:
Prophylaxis of Cardiac Rejection:
Prophylaxis of Hepatic Rejection:
Treatment of First or Refractory Renal Rejection:
Lupus Nephritis Patients:
Induction Therapy:
Maintenance Therapy:
Mycophenolate Mofetil should be used alongside corticosteroids. The dosage should be introduced gradually and adjusted based on clinical response. Therapeutic drug monitoring may be helpful to prevent sub-therapeutic exposure (Cmin≥3.0 mg/L or inter-dose AUC ≥35 h*mg/L). Follow your physician's advice for taking Cellcept 500mg Tablet. Swallow the tablets with water, do not crush or chew them. Dosage varies based on your transplant type. Do not stop the medication abruptly without consulting your doctor.
Before taking Cellcept 500mg Tablet, it's important to inform your doctor if you are taking any of the following medications:
Discuss these medications with your doctor before starting Cellcept 500mg Tablet to ensure safe and effective treatment.
Do not take Cellcept 500mg Tablet if:
Mycophenolate Mofetil is contraindicated in pregnancy and during breastfeeding. The safe use of Mycophenolate Mofetil during labor and delivery has not been established.
Mycophenolic acid tablets should be used with caution because they:
Special Populations:
Overdose:
In case you have taken an excessive amount of this medicine, it's important to contact your doctor or seek medical attention at the nearest hospital immediately.
Missed Dose:
If you have missed a dose of this medicine, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and resume your regular dosing schedule.
Store in a cool and dry place away from sunlight
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